MitoPlantRedoxV1, Main, Exploration, bibRecord, 000220

Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis.

Identifieur interne : 000220 ( Main/Exploration ); précédent : 000219; suivant : 000221

Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis.

Auteurs : Dongxiao Cui [République populaire de Chine] ; Tingting Liang [République populaire de Chine] ; Liqian Sun [République populaire de Chine] ; Liqiang Meng [République populaire de Chine] ; Congcong Yang [République populaire de Chine] ; Liwei Wang [République populaire de Chine] ; Taigang Liang [République populaire de Chine] ; Qingshan Li [République populaire de Chine]

Source :

Pharmaceutical biology [ 1744-5116 ] ; 2018.

RBID : pubmed:30387372

Descripteurs français

KwdFr :
- Apoptose (effets des médicaments et des substances chimiques), Caspase-9 (métabolisme), Cellules HepG2 (MeSH), Crataegus (composition chimique), Espèces réactives de l'oxygène (métabolisme), Extraits de plantes (composition chimique), Extraits de plantes (isolement et purification), Extraits de plantes (pharmacologie), Foie (cytologie), Foie (effets des médicaments et des substances chimiques), Foie (métabolisme), Fruit (composition chimique), Humains (MeSH), Lignée cellulaire (MeSH), Mitochondries (effets des médicaments et des substances chimiques), Mitochondries (métabolisme), Nanoparticules (administration et posologie), Nanoparticules (composition chimique), Oxydoréduction (effets des médicaments et des substances chimiques), Potentiel de membrane mitochondriale (effets des médicaments et des substances chimiques), Protéines proto-oncogènes c-bcl-2 (métabolisme), Stress oxydatif (effets des médicaments et des substances chimiques), Survie cellulaire (effets des médicaments et des substances chimiques), Sélénium (composition chimique), Sélénium (pharmacologie), Technologie de la chimie verte (MeSH), Tumeurs du foie (anatomopathologie), Tumeurs du foie (métabolisme), Tumeurs du foie (traitement médicamenteux).
MESH :
- administration et posologie : Nanoparticules.
- anatomopathologie : Tumeurs du foie.
- composition chimique : Crataegus, Extraits de plantes, Fruit, Nanoparticules, Sélénium.
- cytologie : Foie.
- effets des médicaments et des substances chimiques : Apoptose, Foie, Mitochondries, Oxydoréduction, Potentiel de membrane mitochondriale, Stress oxydatif, Survie cellulaire.
- isolement et purification : Extraits de plantes.
- métabolisme : Caspase-9, Espèces réactives de l'oxygène, Foie, Mitochondries, Protéines proto-oncogènes c-bcl-2, Tumeurs du foie.
- pharmacologie : Extraits de plantes, Sélénium.
- traitement médicamenteux : Tumeurs du foie.
- Cellules HepG2, Humains, Lignée cellulaire, Technologie de la chimie verte.

English descriptors

KwdEn :
- Apoptosis (drug effects), Caspase 9 (metabolism), Cell Line (MeSH), Cell Survival (drug effects), Crataegus (chemistry), Fruit (chemistry), Green Chemistry Technology (MeSH), Hep G2 Cells (MeSH), Humans (MeSH), Liver (cytology), Liver (drug effects), Liver (metabolism), Liver Neoplasms (drug therapy), Liver Neoplasms (metabolism), Liver Neoplasms (pathology), Membrane Potential, Mitochondrial (drug effects), Mitochondria (drug effects), Mitochondria (metabolism), Nanoparticles (administration & dosage), Nanoparticles (chemistry), Oxidation-Reduction (drug effects), Oxidative Stress (drug effects), Plant Extracts (chemistry), Plant Extracts (isolation & purification), Plant Extracts (pharmacology), Proto-Oncogene Proteins c-bcl-2 (metabolism), Reactive Oxygen Species (metabolism), Selenium (chemistry), Selenium (pharmacology).
MESH :
- chemical , chemistry : Plant Extracts, Selenium.
- chemical , isolation & purification : Plant Extracts.
- chemical , metabolism : Caspase 9, Proto-Oncogene Proteins c-bcl-2, Reactive Oxygen Species.
- administration & dosage : Nanoparticles.
- chemistry : Crataegus, Fruit, Nanoparticles.
- cytology : Liver.
- drug effects : Apoptosis, Cell Survival, Liver, Membrane Potential, Mitochondrial, Mitochondria, Oxidation-Reduction, Oxidative Stress.
- drug therapy : Liver Neoplasms.
- metabolism : Liver, Liver Neoplasms, Mitochondria.
- pathology : Liver Neoplasms.
- chemical , pharmacology : Plant Extracts, Selenium.
- Cell Line, Green Chemistry Technology, Hep G2 Cells, Humans.

Abstract

CONTEXT

Selenium nanoparticles (SeNPs) have attracted worldwide attention due to their unique properties and potential bioactivities. Considering that hawthorn is both a traditional medicine and a common edible food, hawthorn fruit extract (HE) was chosen as a reductant to prepare SeNPs.

OBJECTIVE

SeNPs were synthesized by using an aqueous HE as a reductant and stabilizer. The antitumor activities and potential mechanisms of SeNPs were explored by using a series of cellular assays.

MATERIALS AND METHODS

The HE mediated SeNPs (HE-SeNPs) were examined using various characterisation methods. The cytotoxicity was measured against HepG2 cells after treated with 0, 5, 10 and 20 μg/mL of HE-SeNPs for 24 h. Annexin V-FITC/PI staining analysis was performed to observe the apoptosis of HepG2 cells. Additionally, mitochondrial membrane potential (MMP), intracellular reactive oxygen species (ROS) levels were evaluated. Finally, the protein expression levels of caspase-9 and Bcl-2 were identified by Western blot.

RESULTS

The mono-dispersed and stable SeNPs were prepared with an average size of 113 nm. HE-SeNPs showed obvious antitumor activities towards HepG2 cells with an IC

DISCUSSION AND CONCLUSIONS

HE-SeNPs induced intracellular oxidative stress and mitochondrial dysfunction to initiate HepG2 cell apoptosis through the mitochondrial pathway. Therefore, HE-SeNPs may be a candidate for further evaluation as a chemotherapeutic agent for human liver cancer.

DOI: 10.1080/13880209.2018.1510974
PubMed: 30387372
PubMed Central: PMC6225412

Affiliations:

République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000162
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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apoptosis (drug effects)</term>
<term>Caspase 9 (metabolism)</term>
<term>Cell Line (MeSH)</term>
<term>Cell Survival (drug effects)</term>
<term>Crataegus (chemistry)</term>
<term>Fruit (chemistry)</term>
<term>Green Chemistry Technology (MeSH)</term>
<term>Hep G2 Cells (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Liver (cytology)</term>
<term>Liver (drug effects)</term>
<term>Liver (metabolism)</term>
<term>Liver Neoplasms (drug therapy)</term>
<term>Liver Neoplasms (metabolism)</term>
<term>Liver Neoplasms (pathology)</term>
<term>Membrane Potential, Mitochondrial (drug effects)</term>
<term>Mitochondria (drug effects)</term>
<term>Mitochondria (metabolism)</term>
<term>Nanoparticles (administration & dosage)</term>
<term>Nanoparticles (chemistry)</term>
<term>Oxidation-Reduction (drug effects)</term>
<term>Oxidative Stress (drug effects)</term>
<term>Plant Extracts (chemistry)</term>
<term>Plant Extracts (isolation & purification)</term>
<term>Plant Extracts (pharmacology)</term>
<term>Proto-Oncogene Proteins c-bcl-2 (metabolism)</term>
<term>Reactive Oxygen Species (metabolism)</term>
<term>Selenium (chemistry)</term>
<term>Selenium (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Apoptose (effets des médicaments et des substances chimiques)</term>
<term>Caspase-9 (métabolisme)</term>
<term>Cellules HepG2 (MeSH)</term>
<term>Crataegus (composition chimique)</term>
<term>Espèces réactives de l'oxygène (métabolisme)</term>
<term>Extraits de plantes (composition chimique)</term>
<term>Extraits de plantes (isolement et purification)</term>
<term>Extraits de plantes (pharmacologie)</term>
<term>Foie (cytologie)</term>
<term>Foie (effets des médicaments et des substances chimiques)</term>
<term>Foie (métabolisme)</term>
<term>Fruit (composition chimique)</term>
<term>Humains (MeSH)</term>
<term>Lignée cellulaire (MeSH)</term>
<term>Mitochondries (effets des médicaments et des substances chimiques)</term>
<term>Mitochondries (métabolisme)</term>
<term>Nanoparticules (administration et posologie)</term>
<term>Nanoparticules (composition chimique)</term>
<term>Oxydoréduction (effets des médicaments et des substances chimiques)</term>
<term>Potentiel de membrane mitochondriale (effets des médicaments et des substances chimiques)</term>
<term>Protéines proto-oncogènes c-bcl-2 (métabolisme)</term>
<term>Stress oxydatif (effets des médicaments et des substances chimiques)</term>
<term>Survie cellulaire (effets des médicaments et des substances chimiques)</term>
<term>Sélénium (composition chimique)</term>
<term>Sélénium (pharmacologie)</term>
<term>Technologie de la chimie verte (MeSH)</term>
<term>Tumeurs du foie (anatomopathologie)</term>
<term>Tumeurs du foie (métabolisme)</term>
<term>Tumeurs du foie (traitement médicamenteux)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Plant Extracts</term>
<term>Selenium</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Caspase 9</term>
<term>Proto-Oncogene Proteins c-bcl-2</term>
<term>Reactive Oxygen Species</term>
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<keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Nanoparticles</term>
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</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Crataegus</term>
<term>Fruit</term>
<term>Nanoparticles</term>
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<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Crataegus</term>
<term>Extraits de plantes</term>
<term>Fruit</term>
<term>Nanoparticules</term>
<term>Sélénium</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Foie</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Liver</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term>
<term>Cell Survival</term>
<term>Liver</term>
<term>Membrane Potential, Mitochondrial</term>
<term>Mitochondria</term>
<term>Oxidation-Reduction</term>
<term>Oxidative Stress</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Liver Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Apoptose</term>
<term>Foie</term>
<term>Mitochondries</term>
<term>Oxydoréduction</term>
<term>Potentiel de membrane mitochondriale</term>
<term>Stress oxydatif</term>
<term>Survie cellulaire</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Extraits de plantes</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Liver</term>
<term>Liver Neoplasms</term>
<term>Mitochondria</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Caspase-9</term>
<term>Espèces réactives de l'oxygène</term>
<term>Foie</term>
<term>Mitochondries</term>
<term>Protéines proto-oncogènes c-bcl-2</term>
<term>Tumeurs du foie</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Liver Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Extraits de plantes</term>
<term>Sélénium</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Plant Extracts</term>
<term>Selenium</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs du foie</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Cell Line</term>
<term>Green Chemistry Technology</term>
<term>Hep G2 Cells</term>
<term>Humans</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Cellules HepG2</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Technologie de la chimie verte</term>
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<front><div type="abstract" xml:lang="en"><p><b>CONTEXT</b>
</p>
<p>Selenium nanoparticles (SeNPs) have attracted worldwide attention due to their unique properties and potential bioactivities. Considering that hawthorn is both a traditional medicine and a common edible food, hawthorn fruit extract (HE) was chosen as a reductant to prepare SeNPs.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>SeNPs were synthesized by using an aqueous HE as a reductant and stabilizer. The antitumor activities and potential mechanisms of SeNPs were explored by using a series of cellular assays.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>MATERIALS AND METHODS</b>
</p>
<p>The HE mediated SeNPs (HE-SeNPs) were examined using various characterisation methods. The cytotoxicity was measured against HepG2 cells after treated with 0, 5, 10 and 20 μg/mL of HE-SeNPs for 24 h. Annexin V-FITC/PI staining analysis was performed to observe the apoptosis of HepG2 cells. Additionally, mitochondrial membrane potential (MMP), intracellular reactive oxygen species (ROS) levels were evaluated. Finally, the protein expression levels of caspase-9 and Bcl-2 were identified by Western blot.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>The mono-dispersed and stable SeNPs were prepared with an average size of 113 nm. HE-SeNPs showed obvious antitumor activities towards HepG2 cells with an IC</p>
</div>
<div type="abstract" xml:lang="en"><p><b>DISCUSSION AND CONCLUSIONS</b>
</p>
<p>HE-SeNPs induced intracellular oxidative stress and mitochondrial dysfunction to initiate HepG2 cell apoptosis through the mitochondrial pathway. Therefore, HE-SeNPs may be a candidate for further evaluation as a chemotherapeutic agent for human liver cancer.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30387372</PMID>
<DateCompleted><Year>2019</Year>
<Month>01</Month>
<Day>04</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>01</Month>
<Day>04</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1744-5116</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>56</Volume>
<Issue>1</Issue>
<PubDate><Year>2018</Year>
<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>Pharmaceutical biology</Title>
<ISOAbbreviation>Pharm Biol</ISOAbbreviation>
</Journal>
<ArticleTitle>Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis.</ArticleTitle>
<Pagination><MedlinePgn>528-534</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1080/13880209.2018.1510974</ELocationID>
<Abstract><AbstractText Label="CONTEXT" NlmCategory="BACKGROUND">Selenium nanoparticles (SeNPs) have attracted worldwide attention due to their unique properties and potential bioactivities. Considering that hawthorn is both a traditional medicine and a common edible food, hawthorn fruit extract (HE) was chosen as a reductant to prepare SeNPs.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">SeNPs were synthesized by using an aqueous HE as a reductant and stabilizer. The antitumor activities and potential mechanisms of SeNPs were explored by using a series of cellular assays.</AbstractText>
<AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">The HE mediated SeNPs (HE-SeNPs) were examined using various characterisation methods. The cytotoxicity was measured against HepG2 cells after treated with 0, 5, 10 and 20 μg/mL of HE-SeNPs for 24 h. Annexin V-FITC/PI staining analysis was performed to observe the apoptosis of HepG2 cells. Additionally, mitochondrial membrane potential (MMP), intracellular reactive oxygen species (ROS) levels were evaluated. Finally, the protein expression levels of caspase-9 and Bcl-2 were identified by Western blot.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The mono-dispersed and stable SeNPs were prepared with an average size of 113 nm. HE-SeNPs showed obvious antitumor activities towards HepG2 cells with an IC<sub>50</sub>
 of 19.22 ± 5.3 μg/mL. Results from flow cytometry revealed that both early and total apoptosis rates increased after treating with HE-SeNPs. After cells were treated with various concentrations of HE-SeNPs (5, 10 and 20 μg/mL) for 24 h, the total rate increased to 7.3 ± 0.5, 9.7 ± 1.7 and 19.2 ± 1.6%, respectively. Meanwhile, treatment of HE-SeNPs up-regulated intracellular ROS levels and reduced the MMP. In addition, HE-SeNPs induced the up-regulation of caspase-9 and down-regulation of Bcl-2.</AbstractText>
<AbstractText Label="DISCUSSION AND CONCLUSIONS" NlmCategory="CONCLUSIONS">HE-SeNPs induced intracellular oxidative stress and mitochondrial dysfunction to initiate HepG2 cell apoptosis through the mitochondrial pathway. Therefore, HE-SeNPs may be a candidate for further evaluation as a chemotherapeutic agent for human liver cancer.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cui</LastName>
<ForeName>Dongxiao</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>a School of Pharmaceutical Science , Shanxi Medical University , Taiyuan , PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liang</LastName>
<ForeName>Tingting</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>b Shanxi Provincial Hospital of Traditional Chinese Medicine , Taiyuan , PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sun</LastName>
<ForeName>Liqian</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>a School of Pharmaceutical Science , Shanxi Medical University , Taiyuan , PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Meng</LastName>
<ForeName>Liqiang</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>a School of Pharmaceutical Science , Shanxi Medical University , Taiyuan , PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Congcong</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>a School of Pharmaceutical Science , Shanxi Medical University , Taiyuan , PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Liwei</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>a School of Pharmaceutical Science , Shanxi Medical University , Taiyuan , PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liang</LastName>
<ForeName>Taigang</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>a School of Pharmaceutical Science , Shanxi Medical University , Taiyuan , PR China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>c Shanxi University of Chinese medicine , Jinzhong , PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Qingshan</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>a School of Pharmaceutical Science , Shanxi Medical University , Taiyuan , PR China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>c Shanxi University of Chinese medicine , Jinzhong , PR China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Pharm Biol</MedlineTA>
<NlmUniqueID>9812552</NlmUniqueID>
<ISSNLinking>1388-0209</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C000595707">BCL2 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019253">Proto-Oncogene Proteins c-bcl-2</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.22.-</RegistryNumber>
<NameOfSubstance UI="C506433">CASP9 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.22.-</RegistryNumber>
<NameOfSubstance UI="D053453">Caspase 9</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>H6241UJ22B</RegistryNumber>
<NameOfSubstance UI="D012643">Selenium</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053453" MajorTopicYN="N">Caspase 9</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D027825" MajorTopicYN="N">Crataegus</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005638" MajorTopicYN="N">Fruit</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055772" MajorTopicYN="N">Green Chemistry Technology</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D056945" MajorTopicYN="N">Hep G2 Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008113" MajorTopicYN="N">Liver Neoplasms</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053078" MajorTopicYN="N">Membrane Potential, Mitochondrial</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008928" MajorTopicYN="N">Mitochondria</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053758" MajorTopicYN="N">Nanoparticles</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010084" MajorTopicYN="N">Oxidation-Reduction</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019253" MajorTopicYN="N">Proto-Oncogene Proteins c-bcl-2</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012643" MajorTopicYN="N">Selenium</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Trace element</Keyword>
<Keyword MajorTopicYN="N">antitumor</Keyword>
<Keyword MajorTopicYN="N">human liver cancer</Keyword>
<Keyword MajorTopicYN="N">mitochondrial pathway</Keyword>
<Keyword MajorTopicYN="N">oxidative stress</Keyword>
</KeywordList>
</MedlineCitation>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Cui, Dongxiao" sort="Cui, Dongxiao" uniqKey="Cui D" first="Dongxiao" last="Cui">Dongxiao Cui</name>
</noRegion>
<name sortKey="Li, Qingshan" sort="Li, Qingshan" uniqKey="Li Q" first="Qingshan" last="Li">Qingshan Li</name>
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	Serveur d'exploration sur les mitochondries dans l'oxydoréduction chez les plantes
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Serveur d'exploration sur les mitochondries dans l'oxydoréduction chez les plantes

Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis.

Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis.

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